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FACTOR XIIA
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DeCS
Descriptor
English
:
Factor XIIa
Descriptor
Spanish
:
Factor XIIa
Descriptor
Portuguese
:
Fator XIIa
Synonyms
English
:
Factor XII, Activated
Coagulation Factor XIIa
Tree Number:
D08.811.277.656.300.760.324
D08.811.277.656.959.350.324
D12.776.124.125.450.324
D23.119.450.324
Definition
English
:
Activated form of
factor XII
. In the initial event in the intrinsic pathway of
blood coagulation
, kallikrein (with cofactor HIGH
MOLECULAR WEIGHT
KININOGEN) cleaves
factor XII
to XIIa.
Factor XIIa
is then further cleaved by kallikrein, plasmin, and
trypsin
to yield smaller
factor XII
fragments (Hageman-Factor fragments). These fragments increase the activity of
prekallikrein
to kallikrein but decrease the procoagulant activity of
factor XII.
Indexing Annotation
English
:
/defic =
FACTOR XII DEFICIENCY
See Related
English
:
Coagulants
History Note
English
:
90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24648
Unique Identifier:
D015956
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS